Question 1

The vascular system acts to prevent bleeding by which mechanism(s) ?

Accepted Answer

A)   Vasoconstriction and reflex stimulation of adjacent vessels
B)   Diversion of blood flow around damaged vasculature
C)   Initiation of contact-activation of platelets with subsequent aggregation
D)   Contact-activation of the coagulation system leading to fibrin formation
E)   All of the aboveF) A) and D)
G) None of the above

Question 2

All of the following are characteristics of the fibrinogen group of coagulation proteins except:

Accepted Answer

A)   High-molecular-weight proteins.
B)   Factors are not absorbed by BaSO4.
C)   Factors are consumed during the coagulation process.
D)   Factors V and VIII are the most stabile and therefore present in stored plasma.
E)   Factors are increased during inflammation and pregnancy.F) All of the above
G) A) and D)

Question 3

What role do membrane phospholipids play in the coagulation process?

Accepted Answer

A)   They are inhibitors of cyclo-oxygenase.
B)   They are responsible for the synthesis of TXA2.
C)   They provide a catalytic surface for the activation of various clotting factors.
D)   They convert fibrinogen to fibrin.
E)   None of the aboveF) B) and E)
G) None of the above

Question 4

The X monomer is the result of:

Accepted Answer

A)   Prothrombin splitting off pieces of the alpha and beta polypeptide from fibrinogen
B)   Thrombin splitting off pieces of the alpha and beta polypeptide from fibrinogen
C)   Plasmin splitting off pieces of the alpha and beta polypeptide and gamma polypeptide from fibrinogen
D)   Plasmin splitting off pieces of the alpha and beta polypeptide and gamma polypeptide from fibrin
E)   None of the aboveF) A) and B)
G) All of the above

Question 5

What is necessary for platelet aggregation?

Accepted Answer

A)   ADP
B)   Fibrinogen
C)   Calcium
D)   All of the above
E)   None of the aboveF) A) and D)
G) B) and C)

Question 6

__________ is a reversible process whereby platelets stick to a foreign surface.

Accepted Answer

A)   Aggregation
B)   Adhesion
C)   Reverse reaction
D)   Agglutination
E)   SecretionF) A) and B)
G) A) and C)

Question 7

Factor I is involved with which clotting pathway?

Accepted Answer

A)   Intrinsic
B)   Extrinsic
C)   Common
D)   A and B
E)   All of the aboveF) A) and D)
G) A) and B)

Question 8

Platelet stored products are released through the __________.

Accepted Answer

A)   Glycocalyx
B)   Plasma membrane
C)   OCS
D)   Mitochondria
E)   None of the aboveF) B) and E)
G) C) and D)

Question 9

What is the function of tissue thromboplastin in maintaining vascular integrity?

Accepted Answer

A)   Initiates fibrin formation through the extrinsic pathway of the coagulation system
B)   Initiates fibrin formation through the intrinsic pathway of the coagulation system
C)   Initiates fibrin lysis through the extrinsic pathway of the coagulation system
D)   Initiates fibrin lysis through the intrinsic pathway of the coagulation system
E)   None of the aboveF) C) and D)
G) B) and E)

Question 10

Hageman factor corresponds to __________.

Accepted Answer

A)   Factor Xb, factor I
B)   Factor II
C)   Factor XII
D)   None of the aboveE) A) and D)
F) None of the above

Question 11

Factor IX is involved with which clotting pathway?

Accepted Answer

A)   Intrinsic
B)   Extrinsic
C)   Common
D)   A and B
E)   All of the aboveF) C) and E)
G) All of the above

Question 12

The last stage involved in arresting bleeding after vessel damage is the formation of a __________.

Accepted Answer

A)   Fibrin degradation product
B)   Stable platelet plug
C)   Plasmin synthesizer
D)   Vasodilator
E)   None of the aboveF) None of the above
G) A) and B)

Question 13

Factor VIII is involved with which clotting pathway?

Accepted Answer

A)   Intrinsic
B)   Extrinsic
C)   Common
D)   A and B
E)   All of the aboveF) D) and E)
G) A) and E)

Question 14

What prostaglandin produced in the endothelium is a vasodilator and potent inhibitor of platelet aggregation?

Accepted Answer

A)   TXA2
B)   PGG2
C)   PGI2
D)   PGH2
E)   None of the aboveF) A) and B)
G) A) and C)

Question 15

Plasminogen is activated to plasmin by all of the following except:

Accepted Answer

A)   TPA (tissue plasminogen activator) 
B)   Kallikrein
C)   Calcium
D)   Urokinase
E)   StreptokinaseF) A) and B)
G) A) and C)

Question 16

The peripheral zone is a complex region of the platelet consisting of:

Accepted Answer

A)   Glycocalyx
B)   Plasma membrane
C)   Open canalicular system (OCS) 
D)   Submembranous region
E)   All of the aboveF) D) and E)
G) None of the above

Question 17

Which event activates the common pathway?

Accepted Answer

A)   Activation of factor X by factor VIIa, factor III, and calcium
B)   Activation of factor X by IXa, factor VIII, calcium, and PF3
C)   Activation of factor XII to XIIa
D)   A and C
E)   A and BF) All of the above
G) A) and B)

Question 18

With the exception of factor VIII, all the coagulation factors are produced in the __________.

Accepted Answer

A)   Bone marrow
B)   Liver
C)   Kidney
D)   Spleen
E)   None of the aboveF) A) and D)
G) A) and E)

Question 19

The final fibrin-split products are __________ and __________ fragments generated from one molecule of fibrinogen.

Accepted Answer

A)   X and Y
B)   2D and 1E
C)   Y and D
D)   2X and 1D
E)   E and 2YF) C) and D)
G) B) and E)

Question 20

Which of the following include specificities of plasma membrane receptors within the peripheral zone?

Accepted Answer

A)   ADP
B)   Thrombin
C)   Glycoprotein IIa
D)   Serotonin
E)   All of the aboveF) A) and B)
G) B) and C)

Exam 24: Introduction to Hemostasis

With the exception of factor VIII, all the coagulation factors are produced in the __________.

Correct AnswerverifiedShow Answer

Which of the following include specificities of plasma membrane receptors within the peripheral zone?

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Factor IX is involved with which clotting pathway?

Correct AnswerverifiedShow Answer

The last stage involved in arresting bleeding after vessel damage is the formation of a __________.

Correct AnswerverifiedShow Answer

__________ is a reversible process whereby platelets stick to a foreign surface.

Correct AnswerverifiedShow Answer

What is necessary for platelet aggregation?

Correct AnswerverifiedShow Answer

Hageman factor corresponds to __________.

Correct AnswerverifiedShow Answer

Platelet stored products are released through the __________.

Correct AnswerverifiedShow Answer

Plasminogen is activated to plasmin by all of the following except:

Correct AnswerverifiedShow Answer

Factor I is involved with which clotting pathway?

Correct AnswerverifiedShow Answer

What prostaglandin produced in the endothelium is a vasodilator and potent inhibitor of platelet aggregation?

Correct AnswerverifiedShow Answer

The X monomer is the result of:

Correct AnswerverifiedShow Answer

What role do membrane phospholipids play in the coagulation process?

Correct AnswerverifiedShow Answer

The vascular system acts to prevent bleeding by which mechanism(s) ?

Correct AnswerverifiedShow Answer

The final fibrin-split products are __________ and __________ fragments generated from one molecule of fibrinogen.

Correct AnswerverifiedShow Answer

What is the function of tissue thromboplastin in maintaining vascular integrity?

Correct AnswerverifiedShow Answer

Which event activates the common pathway?

Correct AnswerverifiedShow Answer

All of the following are characteristics of the fibrinogen group of coagulation proteins except:

Correct AnswerverifiedShow Answer

Factor VIII is involved with which clotting pathway?

Correct AnswerverifiedShow Answer

The peripheral zone is a complex region of the platelet consisting of:

Correct AnswerverifiedShow Answer

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The final fibrin-split products are and fragments generated from one molecule of fibrinogen.

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